Registered Data

[CT184]

[01643] Interdisciplinary modeling and experimentation reveal microglia heterogenity during mouse development

  • Session Date & Time : 3D (Aug.23, 15:30-17:10)
  • Type : Contributed Talk
  • Abstract : Microglia, the resident immune cells of the brain, have recently been found to play additional key roles in neuronal development. However, the drivers of microglia maturation remain comparatively unknown. We address this knowledge gap by developing a data-inspired mathematical model for mouse microglia population dynamics. We apply Bayesian inference to fit model parameters to experimental data, leading us to predict (and experimentally verify) that microglia transition from a proliferative to quiescent phenotype following birth.
  • Classification : 92C15, 62F15, 92C37, Bayesian parameter inference; model selection; microglia; population dynamics; data-driven modeling
  • Author(s) :
    • William Duncan Martinson (University of Oxford)
    • Carles Falco (University of Oxford)
    • Marta Pereira (Achucarro Basque Center for Neuroscience)
    • Amanda Sierra (Ikerbasque Basque Foundation for Science)
    • Jose Carrillo (University of Oxford)

[02695] The position of the axon initial segment assembly site can be predicted from the shape of the neuron

  • Session Date & Time : 3D (Aug.23, 15:30-17:10)
  • Type : Contributed Talk
  • Abstract : A unique compartment called the axon initial segment (AIS) was found critical for the proper development of neuronal polarity. It is unclear how AIS is assembled near the proximal end of the axon during axon specification. In this study, we show that the position of the AIS assembly site is correlated with the zero set of the leading eigenfunction of the Laplace-Beltrami operator solved over the geometry of the neuron. We will then discuss the implications from this observation.
  • Classification : 92C20, 92C15
  • Author(s) :
    • Zhuang Xu (The University of New South Wales)
    • Paul Curmi (University of New South Wales)
    • Christopher Angstmann (University of New South Wales)

[01333] Development of Dynamical Systems-Inspired Metrics to Evaluate Immunotherapy Efficacy

  • Session Date & Time : 3D (Aug.23, 15:30-17:10)
  • Type : Industrial Contributed Talk
  • Abstract : Immunotherapy emerged as the new paradigm to treat cancer patients. Computational tools that complement clinical practice are increasingly being used. Standardization of these tools is crucial for their adaptation and widespread implementation. This work contributes in this direction by developing new metrics inspired from dynamical systems and enriching a modular platform that predicts therapeutic issues of combination therapies in immune-oncology, and reduce the burden on clinical trials.
  • Classification : 92C32, 92C42, Quantitative Systems Pharmacology
  • Author(s) :
    • Fahima Nekka (Université de Montréal)
    • Didier Zugaj (Syneos Health)
    • Frédérique Fenneteau (Université de Montréal)
    • Miriam Schirru (Université de Montréal)
    • Hamza Charef (Université de Montréal)
    • Khalil-Elmehdi Ismaili (Université de Montréal)
    • Pierre-Olivier Tremblay (Syneos Health)

[00188] Two-Phase Modelling of Plaque Growth in Early Atherosclerosis

  • Session Date & Time : 3D (Aug.23, 15:30-17:10)
  • Type : Contributed Talk
  • Abstract : We discuss the early stage of atherosclerotic plaque formation within arteries. The production of foam cells characterizes such plaque. Foam cells generate from the differentiated form of monocytes (called macrophages) owing to oxidized low-density lipoprotein (ox-LDL) cholesterol intake. Initially, plaque radius grows exponentially and later on, it stabilizes with time. Such behaviour is due to the death of foam cells owing to the toxicity of excess ox-LDL intake, although ox-LDL enhances foam cell proliferation.
  • Classification : 92C35, 92-10, 76M20, 35B20, 92B05
  • Author(s) :
    • Abdush Salam Pramanik (Department of Mathematics, University of North Bengal)
    • Bibaswan Dey (Department of Mathematics, University of North Bengal)

[00191] Two-Phase Modelling of Subcutaneous Injection of Drugs

  • Session Date & Time : 3D (Aug.23, 15:30-17:10)
  • Type : Contributed Talk
  • Abstract : Various drugs and vaccines are administered through the subcutaneous pathway. The adipose cells within the subcutaneous layer impart structural anisotropy. We address the mechanical response of the adipose tissue in terms of the computed stress fields to understand the pain a patient realizes. Tissue anisotropy instigates the interstitial fluid to generate one or more eddies. Eddies help a low viscous injected drug homogenize when the skin pinching height is high at the injection apply area.
  • Classification : 92C35, 92B05, 92C50, 35B20, 92-10, Mathematical Modeling of Problems on Biological Phenomena
  • Author(s) :
    • Bibaswan Dey (Department of Mathematics, University of North Bengal)
    • Abdush Salam Pramanik (Department of Mathematics, University of North Bengal)
    • Timir Karmakar (Department of Mathematics, National Institute of Technology Meghalaya, India)
    • Kalyan Saha (Department of Mathematics, University of North Bengal)