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1 [CT180]

[CT180]

Session Time & Room

CT180 (1/4) : 3C @A601 [Chair: Paula Vasquez]
CT180 (2/4) : 3D @A601 [Chair: Carmela Moschella]
CT180 (3/4) : 3E @A601 [Chair: Bootan Rahman]
CT180 (4/4) : 4C @A601 [Chair: Sanjeev Kumar]

Classification

CT180 (1/4) : Mathematical biology in general (92B)
CT180 (2/4) : Mathematical biology in general (92B)
CT180 (3/4) : Biology and other natural sciences (92-) / Mathematical biology in general (92B)
CT180 (4/4) : Mathematical biology in general (92B) / Biology and other natural sciences (92-)

[00300] Coupling macro-micro simulations in complex fluids

Session Time & Room : 3C (Aug.23, 13:20-15:00) @A601
Type : Contributed Talk
Abstract : Some of the most remarkable properties and functions served by some complex fluids originate from the interplay between external fields and microstructural dynamics. From a computational point of view this generates a set of challenges related to the need of coupling dynamics at different length and times scales, sometimes spanning several orders of magnitude. Micro-macro simulations have gained a lot of recognition within the field because these methods allow capturing full dynamics at the macroscale without losing resolution at the microscale. In this talk, we will review our efforts to couple existing macroscopic solvers for the Navier-Stokes equations with microstructural dynamics described by Langevin-type equations. In particular, we will discuss dumbbells models -under viscometric and capillary thinning flows fields- and parallel computing using GPUs.
Classification : 92B05, 76A05, 76A10, 76D05, 97M60
Format : Talk at Waseda University
Author(s) :
- Paula A Vasquez (University of South Carolina)
- Michael Cromer (RIT)

[00035] Effects of toxicity and zooplankton selectivity under seasonal pattern of viruses on plankton dynamics

Session Time & Room : 3C (Aug.23, 13:20-15:00) @A601
Type : Contributed Talk
Abstract : A mathematical model for the interacting dynamics of phytoplankton-zooplankton is proposed. The phytoplankton have ability to take refuge and release toxins to avoid over predation by zooplankton. The zooplankton are provided some additional food to persist in the system. The phytoplankton are assumed to be affected directly by an external toxic substance whereas zooplankton are affected indirectly by feeding on the affected phytoplankton. We incorporate seasonal variations in the model, assuming the level of nutrients, refuge and the rate of toxins released by phytoplankton as functions of time. Our results show that when high toxicity and refuge cause extinction of zooplankton, providing additional food supports the survival of zooplankton population and controls the phytoplankton population. Prey refuge and additional food have stabilizing effects on the system; higher values of the former results in extinction of zooplankton whereas phytoplankton disappear for larger values of the latter. Seasonality in nutrients level and toxins released by phytoplankton generates higher periodic solutions while time-dependent refuge of phytoplankton causes the occurrence of a period-three solution. The possibility of finding additional food for zooplankton may push back the ecosystem to a simple stable state from a complex dynamics.
Classification : 92B05, 92D25, 92D30, 37A50, 34D05
Format : Online Talk on Zoom
Author(s) :
- Samares Pal (University of Kalyani)

[00375] Modelling Typhoid Fever Transmission: Optimal control and Cost-Effectiveness Analysis

Session Time & Room : 3C (Aug.23, 13:20-15:00) @A601
Type : Industrial Contributed Talk
Abstract : Typhoid fever has been a public health challenge globally, most especially in the developing countries where sanitation and personal hygiene are not taken serious coupled with non-availability of safe-drinking water. In this paper, a deterministic mathematical model of direct and indirect mode of transmission of Typhoid fever dynamics is formulated to investigate the influence of limited clinical efficacy of antibiotics administer to patients suffering from the disease with optimal control and cost-effectiveness analysis. Typhoid fever has been a public health challenge globally, most especially in the developing countries where sanitation and personal hygiene are not taken serious coupled with non-availability of safe-drinking water. In this paper, a deterministic mathematical model of direct and indirect mode of transmission of Typhoid fever dynamics is formulated to investigate the influence of clinical efficacy of antibiotics administer to patients suffering from the disease. The basic reproduction number is analytically computed, and existence and local stability condition of disease-free equilibrium is investigated. Subsequently, the global sensitivity analysis of the model parameters is computed. The optimal control and cost-effectiveness analysis were also computed. Our results suggest that hygiene practice and awareness campaign, and disinfection or sterilization or bacteria decay control is the most cost-effective in eliminating the disease from the population and from preventing the susceptible individuals from contracting the bacteria disease.
Classification : 92BXX, 92-XX, 92-10, 91-XX, 91-10, Mathematical modeling of infectious disease(Biomathematics)
Author(s) :
- kazeem Austin TIJANI (Federal University of Agriculture(J. S Tarka university), Makurdi)
- Chinwendu Emilian MADUBUEZE (Federal university of Agriculture Makurdi Nigeria )
- Iortyer Reuben GWERYINA (Federal university of Agriculture(J.S. Tarka University), Makurdi))

[00892] Predicting response to pediatric leukemia with flow cytometry data

Session Time & Room : 3C (Aug.23, 13:20-15:00) @A601
Type : Contributed Talk
Abstract : 15% of children with B-cell acute lymphoblastic leukemia fail to achieve response or long-term remission. With new treatments being developed to provide an alternative for this subset of patients, an improved risk classification at diagnosis can help to plan and prepare for this eventuality. Flow cytometry is currently used to characterize the leukemic clone but it has no prognosis value. In this work we use flow cytometry data at diagnosis from 250 pediatric patients from hospitals in Spain to find features associated with response by means of an array of computational methods.
Classification : 92Bxx
Author(s) :
- Alvaro Martínez-Rubio (University of Cadiz)
- Salvador Chulián (University of Cádiz)
- Ana Niño-López (Department of Mathematics, Universidad de Cádiz)
- Víctor Manuel Pérez-García (University of Castilla-La Mancha)
- María Rosa (University of Cadiz)

[00697] Vicsek-Kuramoto system in collective dynamics and their macroscopic equations

Session Time & Room : 3D (Aug.23, 15:30-17:10) @A601
Type : Contributed Talk
Abstract : In this project we investigate a 'Vicsek-style' model, where noisy self-propelled particles align orientation and angular velocity through interaction with their neighbours. This work has been inspired by the model introduced by Chen, C. et al. Nature (2017) to describe the behaviour of dense colony of bacteria, which self-organize into robust collective oscillatory motion. The main focus is to investigate how individual-level behaviours influence the emergence of macroscopic patterns.
Classification : 92B05, 82C31
Format : Talk at Waseda University
Author(s) :
- Carmela Moschella (University of Vienna )

[00725] Role of CXCL12 in regulation of T cell invasion

Session Time & Room : 3D (Aug.23, 15:30-17:10) @A601
Type : Contributed Talk
Abstract : In this study, we investigate the mutual interactions between the CD8+ T cells and the CXCL12 that prevent T cell invasion by developing mathematical models that involve taxis-reaction-diffusion. We apply the mathematical model to a Boyden invasion assay used in the experiments to demonstrate that the over-expressed CXCL12 can prevent T cell infiltration into tumor. Moreover, we consider tumor-immune dynamics by a hybrid approach and investigate the fundamental mechanism of cytokine shield.
Classification : 92B05, 92C17, 92C45, 92C50
Format : Talk at Waseda University
Author(s) :
- Junho Lee (Konkuk University)
- Yangjin Kim (Konkuk University)
- Chaeyoung Lee (Korea University)

[00480] Mathematics, the Mind and Alzheimer's disease: Systematical progression on brain graphs

Session Time & Room : 3D (Aug.23, 15:30-17:10) @A601
Type : Contributed Talk
Abstract : Neurodegenerative diseases, Alzheimer's disease (AD) in particular, present a clear challenge to modern medicine due to brain delicate in vivo environment and limited insight from the human whole nervous system. Mathematical network models of dementia, such as AD, offer a path forward that can be deployed using the multitude of anatomical brain-graph data from real human patients. The dynamical processes of the model support front-like propagation on networks, where an initial localized perturbation grows and systematically invades all nodes in the network. The main question is to understand its overall dynamics. For instance, if a process starts at a seed location, how long will it take to appear at other locations, and then develop through a full-scale invasion, leading to dementia for the brain? The arrival-time problem, that consists in determining the time it takes for a quantity of interest to reach a certain level at each node, greatly depends on the coupling dynamics between nodes. In this talk, I address a question to extract estimates for the dynamics motivated by the study of toxic protein propagation in neurodegenerative diseases: if a single node is seeded at a small concentration, when will other nodes reach the same initial concentration? My research demonstrates that different estimates can give their important insights to understand the dynamics and, in particular, analytical methods to estimate and compute the arrival times are extremely powerful and can capture essential features in AD.
Classification : 92B05, General biology and biomathematics
Format : Talk at Waseda University
Author(s) :
- Prama Setia Putra (Mathematical Institute, University of Oxford)
- Prama Setia Putra (Mathematical Institute, University of Oxford)
- Alain Goriely (Mathematical Institute, University of Oxford)

[00713] Mathematical Modeling of Lymphatic Filariasis-Buruli ulcer co-infection

Session Time & Room : 3D (Aug.23, 15:30-17:10) @A601
Type : Industrial Contributed Talk
Abstract : A mathematical model for Lymphatic Filariasis -Buruli ulcer co-infection is explored to provide a theoretical analysis of the disease's dynamics. The disease free equilibrium is proved to be locally asymptotically stable; the model was found to be showing transcritical and backward bifurcation, time dependent controls are incorporated to obtain necessary conditions for optimal control of the diseases. Numerical simulation results suggest best strategy in controlling the diseases is using all the controls at the same time.
Classification : 92B05, 37G10
Author(s) :
- Helen Olaronke Edogbanya (Federal University Lokoja, Kogi State)
- Helen Olaronke Edogbanya (Federal University Lokoja)
- Zamurat Ayobami Adegboye (Institute of Mathematical and Physcical Sciences, IMSP-UAC, Dangbo)

[01364] Time-Delay Systems: An Overview

Session Time & Room : 3E (Aug.23, 17:40-19:20) @A601
Type : Contributed Talk
Abstract : Time-delay naturally arises in many real-world systems, due to the fact that the instantaneous rate of change of such systems does not only depend on their current time but rather on their previous history as well. Hence, time-delays are ubiquitous, their introduction often leads to suppression of oscillations, multistability and chaotic motion in the dynamical systems. This talk presents some models with different kinds of time-delays such as discrete, distributed and combination of both discrete and distributed time-delays with special emphasis on the reason of incorporating such delays into the system
Classification : 92-10, 34D20
Format : Talk at Waseda University
Author(s) :
- Bootan Rahman (University of Kurdistan Hewler (UKH))

[01187] Dynamic, data-driven neurodegeneration: Modelling clearance and proteopathy in Alzheimer’s disease

Session Time & Room : 3E (Aug.23, 17:40-19:20) @A601
Type : Contributed Talk
Abstract : The clinical research community has raised the alarm on the importance of studying the role of clearance in Alzheimer’s disease. We heed this alarm by developing and analysing the first network reaction-diffusion dynamical system coupling clearance and proteopathy. Analytical insights, and computational results on high-resolution brain graphs constructed from human data, demonstrate the connections between clearance and neurodegeneration. Our results suggest clearance deficits may play an important role in the onset and trajectory of Alzheimer's.
Classification : 92-10, 37N25
Author(s) :
- Georgia Staf Brennan (University of Oxford)
- Alain Goriely (University of Oxford)
- Marie Rognes (Simula Research Laboratory)
- Travis Thompson (Texas Tech University)
- Hadrien Oliveri (University of Oxford)

[00828] Role of NK cells in regulation of lung cancer progression

Session Time & Room : 3E (Aug.23, 17:40-19:20) @A601
Type : Contributed Talk
Abstract : Tumor-associated neutrophils (TANs) and STAT signaling can stimulate or inhibit tumor growth. We developed and analyzed a mathematical model to address the issues of phenotypic transition and nonlinear regulation of NK cells, thus tumor dynamics, in response to various biochemical stimuli. Several optimal tumor prevention strategies including NK cells and Ionizing radiation have been developed to slow tumor growth. Therefore, We suggested how the optimal combination of anticancer treatments.
Classification : 92B05, 92-04, 92-10, Mathematical Biology
Format : Talk at Waseda University
Author(s) :
- Donggu Lee (Konkuk University)

[00927] Bone marrow stem cells and exosomes control doxorubicin-induced CRCC: A mathematical model

Session Time & Room : 3E (Aug.23, 17:40-19:20) @A601
Type : Contributed Talk
Abstract : Doxorubicin (DOX), a widely used chemotherapeutic agent, can cause neurodegeneration in the brain, which leads to cancer-related cognitive changes (CRCC). In fact, CRCC is a deteriorating condition which adversely affects the day-to-day life of cancer survivors. Recent studies reported that bone marrow mesenchymal stem cells (BMSCs) and exosome may significantly affect the CRCC conditions in a combination therapy (DOX+Exosome). In this study, we investigate the interaction among intracellular signaling (NFκB-Bcl-2-BAX), DOX, exosome, and IL-6.
Classification : 92B05
Format : Talk at Waseda University
Author(s) :
- hyungchul Kim (Konkuk University)
- Donggu Lee (Konkuk University)
- Haneol Cho (Konkuk university)
- Junho Lee (Konkuk University)
- Yangjin Kim (Konkuk University)

[01160] A mathematical study of cancer and radiotherapy towards personalized medicine

Session Time & Room : 3E (Aug.23, 17:40-19:20) @A601
Type : Contributed Talk
Abstract : We present a mathematical model that describes the growth of a tumor mass, considering the interaction between the microenvironment abiotic factors and the epigenetic composition of the cancer cell population. We show the dynamics of its effects on radiotherapy treatment. Results reveal the predictive and diagnostic value of the use of mathematical models as an aid to the medical image in outlining patient-specific therapeutic protocols and optimizing the effectiveness and relapse control.
Classification : 92B05, 65M60
Format : Online Talk on Zoom
Author(s) :
- Giulia Chiari (Politecnico di Torino)

[01630] Analysis of blood flow through multiple stenoses in a narrow artery

Session Time & Room : 4C (Aug.24, 13:20-15:00) @A601
Type : Contributed Talk
Abstract : A study of the effects of blood flow parameters in narrow arteries having multiple stenoses is made here, where the blood is considered as a non-Newtonian Kuang-Luo (K-L) fluid model, with no-slip conditions at the arterial wall. In fact, the main properties of K-L fluid model are that the plasma viscosity and yield stress play a very important role. These parameters make this fluid remarkably similar to blood, however, when we change these parameters the flow characteristics change significantly. We have derived a numerical expression for the blood flow characteristics such as resistance to blood flow, blood flow rate, axial velocity, and skin friction. These numerical expressions have been solved by MATLAB 2021 software and discussed graphically. Furthermore, these results have been compared with Newtonian fluid and observation made that resistance to blood flow and skin friction is decreased when blood is changed from non-Newtonian to Newtonian fluid.
Classification : 92B05, 92C30, 76Z05
Format : Talk at Waseda University
Author(s) :
- Sanjeev Kumar (Dr. Bhimrao Ambedkar University, Agra)
- Rashmi Sharma (Dr. Bhimrao Ambedkar University)
- Amendra Singh (Dr. Bhimrao Ambedkar University)

[01463] Chemical Signalling and Pattern Formation in Predator-Prey Models

Session Time & Room : 4C (Aug.24, 13:20-15:00) @A601
Type : Contributed Talk
Abstract : Random movement of species is well documented to put forward Turing instability in predator-prey models . On the other hand recent studies suggest that directed movement of species known as direct taxis leads to stabilization of steady state and no patterns emerge. However the importance of chemical cues in predator-prey interactions is still a topic of contention among ecologists. Source of chemicals to which prey species respond often originate as cues released by the predators which lead to directed movement of prey individuals opposite to the concentration of chemicals. This movement of prey individuals opposite to the gradient of chemical is known as indirect predator taxis. This talk will introduce an advection-reaction-diffusion mathematical model to understand the impact of chemical induced anti-predation defense in a special class of predator-prey system. The reaction part considers Schoener's model of intraguild-predation which has no periodic solution. We will discuss uniqueness and existence of classical solutions, linear stability analysis results and conditions for the pattern formation. We will show that random diffusion forces constant steady state to be stable and only directed movement of prey individuals has ability to destabilizes the constant steady state and spatio-temporal patterns emerge. We numerically show emergence of spatio-temporal patterning that depicts the tendency to spatio-temporal separation between prey and predators.
Classification : 92B05, Mathematical Biology, Partial Differential Equations
Format : Online Talk on Zoom
Author(s) :
- Purnedu Mishra (Norwegian University of Life Sciences Norway)
- Prof. Darius Wrzosek (Norwegian University of Life Sciences)

[00931] The vaginal microbiota and its association with Chlamydia infection

Session Time & Room : 4C (Aug.24, 13:20-15:00) @A601
Type : Contributed Talk
Abstract : Chlamydia trachomatis is the most common bacterial sexually transmitted infection in the U.S. While genital chlamydia infection can beget devastating pathologies, it is unclear why some women are more likely to develop severe infections but others are asymptomatic or remain uninfected after exposure to C. trachomatics. We use mice as a model organism, seek to evaluate the potential impact of the time of day of pathogen exposure on the genital tract microbiome in chlamydia infection.
Classification : 92B05, 92C70
Format : Online Talk on Zoom
Author(s) :
- Lihong Zhao (University of California Merced)
- Lihong Zhao (University of California Merced)

[02680] An analysis of a model of fear in disease transmission

Session Time & Room : 4C (Aug.24, 13:20-15:00) @A601
Type : Contributed Talk
Abstract : A model for disease transmission has been proposed that includes fear response both to disease and vaccine. It has been shown numerically that public health restrictions can create a bifurcation in the final size of the epidemic. In this talk we analyze this model to determine analytic conditions for stability and bifurcations to final disease size. We modify the model with additional terms such as adverse reactions from disease and a double-fear compartment.
Classification : 92-10, 92D30, 91D30, 91F99
Format : Talk at Waseda University
Author(s) :
- Iain Moyles (York University)
- Rebecca Tyson (University of British Columbia Okanagan)
- Avneet Kaur (University of British Columbia Okanagan)

[01734] Towards A Modeling Framework For Pediatric Sickle Cell Pain

Session Time & Room : 4C (Aug.24, 13:20-15:00) @A601
Type : Contributed Talk
Abstract : Sickle cell pain presents in acute episodes in pediatric patients, as opposed to the chronic pain observed in adults. This episodic nature necessitates a distinct approach from those used to model adult pain. Statistical studies have examined interactions between sleep actigraphy measurements and pain levels in pediatric populations, and we propose a dynamic model of pediatric pain that incorporates sleep effects over varying time windows. Our aim is to determine markers of future pain episodes.
Classification : 92-10, 37N25, 65P99, 62P10
Format : Talk at Waseda University
Author(s) :
- Reginald McGee (College of the Holy Cross)
- Angela Reynolds (Virginia Commonwealth University)
- Quindel Jones (Virginia Commonwealth University)
- Rebecca Segal (Virginia Commonwealth University)
- Wally Smith (Virginia Commonwealth University)
- Cecelia Valrie (Virginia Commonwealth University)