[02615] Theory of the cell motility mechanism in the absence of adhesions
Session Time & Room : 4E (Aug.24, 17:40-19:20) @D514
Type : Contributed Talk
Abstract : The existing paradigm of the cell motility cycle does not hold for in vivo cell movement in complex 3D environments. In physiologically relevant environments, cells frequently use pressure-driven round membrane protrusions for locomotion. The role of substrate adhesion is minimal, and it remains unknown if and how a cell can migrate without any adhesions. Here, we leverage modeling and computational tools to reveal the step-by-step cycle of locomotion for cells that use blebs as leading-edge protrusions in confined environments. We show that cells cannot effectively migrate when the cell cortex is a purely elastic material, even with asymmetric channel geometry. Cells migrate effectively if actin turnover is included with a viscoelastic description for the cortex. Lastly, we compare with previous experimental findings and identify the spatiotemporal force distribution during a motility cycle.
