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[02158] Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping

  • Session Time & Room : 4E (Aug.24, 17:40-19:20) @D514
  • Type : Contributed Talk
  • Abstract : The mammalian circadian clock is based on a self-sustaining transcriptional-translational negative feedback loop. This machinery is expected to suffer from the heterogeneous arrival time distribution of clock protein from the noisy intracellular environment at the nucleus; however, mammals exhibit robust daily rhythms of physiological and behavioral processes, including sleep and hormone secretion. We explore under which condition the circadian clock compensates for the heterogeneity by a modeling approach.
  • Classification : 92BXX, 92Cxx
  • Format : Talk at Waseda University
  • Author(s) :
    • Seokjoo Chae
    • Dae Wook Kim (University of Michigan)
    • Seunggyu Lee (Korea University)
    • Jae Kyoung Kim (KAIST)