Session Time & Room : 4E (Aug.24, 17:40-19:20) @D514
Type : Contributed Talk
Abstract :
The mammalian circadian clock is based on a self-sustaining transcriptional-translational negative feedback loop. This machinery is expected to suffer from the heterogeneous arrival time distribution of clock protein from the noisy intracellular environment at the nucleus; however, mammals exhibit robust daily rhythms of physiological and behavioral processes, including sleep and hormone secretion. We explore under which condition the circadian clock compensates for the heterogeneity by a modeling approach.
