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[01826] Environmental Feedbacks from the Warburg Effect in Pre-Metastatic Neoplasms

  • Session Time & Room : 1C (Aug.21, 13:20-15:00) @
  • Type : Contributed Talk
  • Abstract : Unusual metabolism is a hallmark of cancer know as the Warburg effect. The methodology of eco-evolutionary games can describe this effect. We mathematically model the game between two metabolic strategies in the neoplasm: oxidative phosphorylation vs glycolysis. We show that our model results in 5 possible dynamic regimes. We conclude that lower glucose uptake rates for glycolytic cells help maintain less dangerous non-glycolytic tumors and hinder early tumor progression. This conclusion provides new treatment insights.
  • Classification : 92D25, 92D40, 91A22
  • Author(s) :
    • Mark Steven Lovett (Dartmouth College)
    • Erol Akçay (University of Pennsylvania)
    • Andrew Tilman (USDA: Forestry service)
    • Artem Kaznatcheev (Department of Mathematics and Department of Information and Computing Sciences, Utrecht University.)