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[01748] Large-scale mRNA translation and the intricate effects of competition for the finite pool of ribosomes

  • Session Time & Room : 3D (Aug.23, 15:30-17:10) @G402
  • Type : Contributed Talk
  • Abstract : We develop a mathematical network model based on balance non-linear first order ordinary differential equations to study large-scale simultaneous mRNA translation in the cell. The central feature of the model is that it is a cooperative system and this property guarantees the monotonicity of the flow. We derive that trajectories within each level set of the first integral globally converge to the fixed point. One of our findings is that raising the drop-off rate in an mRNA that is "jammed" by ribosomes can increase the network's overall protein synthesis rate.
  • Classification : 34E10, 37N25, 92-10, 93D20
  • Format : Talk at Waseda University
  • Author(s) :
    • Aditi Jain (IIT Ropar)
    • Michael Margaliot (Tel Aviv University)
    • Arvind Kumar Gupta (IIT Ropar)