[00859] A mathematical model of immunotherapy: CD19 relapses in B leukemia
Session Time & Room : 3D (Aug.23, 15:30-17:10) @A511
Type : Contributed Talk
Abstract : B-cell Acute Lymphoblastic Leukemia (B-ALL) is the most common type of pediatric leukaemia. For relapsing patients, a treatment possibility is chimeric antigenic receptor (CAR)-T cells, which recognize target cells with the antigen CD19, expressed in B-ALL. We show a mathematical model based on partial differential equations and focus on how CAR-T cell therapy can lead to positive or negative CD19 relapses. The analysis presented represents real-life scenarios, where optimal treatment can be studied.
