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[00859] A mathematical model of immunotherapy: CD19 relapses in B leukemia

  • Session Time & Room : 3D (Aug.23, 15:30-17:10) @A511
  • Type : Contributed Talk
  • Abstract : B-cell Acute Lymphoblastic Leukemia (B-ALL) is the most common type of pediatric leukaemia. For relapsing patients, a treatment possibility is chimeric antigenic receptor (CAR)-T cells, which recognize target cells with the antigen CD19, expressed in B-ALL. We show a mathematical model based on partial differential equations and focus on how CAR-T cell therapy can lead to positive or negative CD19 relapses. The analysis presented represents real-life scenarios, where optimal treatment can be studied.
  • Classification : 92-10, 37N25, 35Q92
  • Format : Online Talk on Zoom
  • Author(s) :
    • Salvador Chulián (Department of Mathematics, University of Cádiz)
    • Álvaro Martínez-Rubio (Department of Mathematics, University of Cádiz)
    • Ana Niño-López (Department of Mathematics, Universidad de Cádiz)
    • María Rosa (Department of Mathematics,)