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[00745] Fluid flow and nutrient transport in hollow fibre membrane bioreactors

  • Session Time & Room : 3C (Aug.23, 13:20-15:00) @A511
  • Type : Contributed Talk
  • Abstract : We present an axisymmetric model of fluid flow through a hollow fibre membrane bioreactor for applications in tissue engineering. We derive a reduced model by exploiting the small aspect ratio of bioreactor radius to length. Coupled to a system of reduced-order advection-reaction-diffusion equations for nutrient transport, we reveal how nutrient delivery to cells depends on membrane permeability. We then determine how spatial variations in scaffold permeability can be established to tune nutrient delivery to cells.
  • Classification : 92-10, 92C35, 76Z05, 92C50, 76D08, Tissue Engineering
  • Format : Online Talk on Zoom
  • Author(s) :
    • George Booth (University of Oxford)
    • Mohit Dalwadi (University College London)
    • Cathy Ye (University of Oxford)
    • Pierre-Alexis Mouthuy (University of Oxford)
    • Sarah Waters (University of Oxford)