Registered Data

[00725] Role of CXCL12 in regulation of T cell invasion

  • Session Time & Room : 3D (Aug.23, 15:30-17:10) @A601
  • Type : Contributed Talk
  • Abstract : In this study, we investigate the mutual interactions between the CD8+ T cells and the CXCL12 that prevent T cell invasion by developing mathematical models that involve taxis-reaction-diffusion. We apply the mathematical model to a Boyden invasion assay used in the experiments to demonstrate that the over-expressed CXCL12 can prevent T cell infiltration into tumor. Moreover, we consider tumor-immune dynamics by a hybrid approach and investigate the fundamental mechanism of cytokine shield.
  • Classification : 92B05, 92C17, 92C45, 92C50
  • Format : Talk at Waseda University
  • Author(s) :
    • Junho Lee (Konkuk University)
    • Yangjin Kim (Konkuk University)
    • Chaeyoung Lee (Korea University)