[00725] Role of CXCL12 in regulation of T cell invasion
Session Time & Room : 3D (Aug.23, 15:30-17:10) @A601
Type : Contributed Talk
Abstract : In this study, we investigate the mutual interactions between the CD8+ T cells and the CXCL12 that prevent T cell invasion by developing mathematical models that involve taxis-reaction-diffusion. We apply the mathematical model to a Boyden invasion assay used in the experiments to demonstrate that the over-expressed CXCL12 can prevent T cell infiltration into tumor. Moreover, we consider tumor-immune dynamics by a hybrid approach and investigate the fundamental mechanism of cytokine shield.
