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[00709] Mathematical modeling reveals P2X1 purinoceptor antagonist as a male contraceptive

  • Session Time & Room : 5D (Aug.25, 15:30-17:10) @D514
  • Type : Contributed Talk
  • Abstract : Condoms and vasectomies are the only male contraceptive options with disruption of foreplay and reversibility issues. The vas deferens smooth muscle (VDSM) contracts for sperm transportation. The pharmacological inhibition of VDSM contraction might explore promising new contraceptives. We established a mathematical model of VDSM cell using ordinary differential equations for an insilico electrophysiological investigation. The findings from our mathematical model reveal that the P2X1-purinoceptors antagonist 2-phenyl-5,6,7,8- tetrahydroquinoxaline might be considered as a new male contraceptive.
  • Classification : 92-08, 92-10, 92-05
  • Format : Online Talk on Zoom
  • Author(s) :
    • CHITARANJAN MAHAPATRA (Paris-Saclay Institute of Neuroscience - CNRS)
    • Ashish Kumar Pradhan (Indian Institute of Sciences Bangalore)