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[00589] Computational Biomedical Physics and Mechanics

  • Session Time & Room : 5B (Aug.25, 10:40-12:20) @D514
  • Type : Proposal of Minisymposium
  • Abstract : Computational methods play a fundamental role in modern science and health research. This symposium is aimed to provide a platform to get computational experts to share recent simulation efforts in areas of biomedical physics and mechanics. The topics include but are not limited to biomedical fluid dynamics, treatment planning and computational surgery, anatomical modeling from medical imaging, multi-physics modeling of biological processes, medical acoustics applied to hyperthermia and focused ultrasound therapy, ion channels/transporters study by continuum models, kinetic models and molecular dynamics.
  • Organizer(s) : Tzyy-Leng Horng, Maxim Solovchuk
  • Classification : 92C05, 92C10, 92C30, 92C35, 92C50
  • Minisymposium Program :
    • 00589 (1/1) : 5B @D514 [Chair: Tzyy-Leng Horng]
      • [01471] A Multi-Scale Approach to Model K+ Permeation Through the KcsA Channel
        • Format : Talk at Waseda University
        • Author(s) :
          • Tzyy-Leng Horng (Feng Chia University)
          • Ren-Shiang Chen (Tunghai University)
          • Maria Vittoria Leonardi (University of Perugia)
          • Fabio Franciolini (University of Perugia)
          • Luigi Catacuzzeno (University of Perugia)
        • Abstract : K+ channels allow a very efficient passage of K+ ions through the membrane while excluding Na+ ions, which is essential for life. The 3D structure of the KcsA K+ channel allows to address many relevant aspects of K+ permeation and selectivity mechanisms at the molecular level. Using a multi-scale approach, we studied the mechanism of K+ permeation through KcsA channels and reproduced the main permeation properties of the KcsA channel found experimentally.
      • [02551] Modeling electrohydrodynamic flow through a nanochannel
        • Format : Talk at Waseda University
        • Author(s) :
          • Kumar Saurabh (National Health Research Institutes)
          • Maxim A Solovchuk (National Health Research Institutes)
        • Abstract : Fluid-ion transport through a nanochannel can be described through coupled fourth order-Poisson-Nernst- Planck-Bikerman (4PNPBik) and Navier-Stokes equations. The 4PNPBik model describes ionic and nonionic interactions between particles while accounting for the effect of polarization of the medium, electrostatic correlations, solvation of ions etc. Navier-Stokes equations model the hydrodynamics of the system. Governing equations are discretized using lattice Boltzmann method on GPU. Impact of phenomenon like viscoelectric effect, finite size of particles, velocity slip, non-homogeneous diffusion etc. has been studied.
      • [02740] Double diffusion for nanofluid
        • Format : Talk at Waseda University
        • Author(s) :
          • Yende Chou (National Taiwan University)
          • Maxim A Solovchuk (National Health Research Institutes)
          • Wei-Shien Hwang (National Taiwan University)
        • Abstract : In double diffusion problems, fluid is driven by temperature and concentration differences within the flow field. By adding nanoparticles into the fluid to form a nanofluid, heat transfer and mass transfer can be enhanced. This study investigates the effect of volume fraction of nanoparticles on heat and mass transfer in a three-dimensional square cavity. The governing equations for this problem are mass conservation, momentum conservation, energy conservation and mass transfer equations. The finite volume method is applied to discretize these equations. Multigrid method is developed for the solution of flow problem to improve computational efficiency.
      • [03003] GPU Computation of High-Intensity Focused Ultrasound Ablation Under Different Pathways
        • Format : Talk at Waseda University
        • Author(s) :
          • Tatiana Filonets (National Taiwan University)
          • Maxim Solovchuk (National Health Research Institutes)
        • Abstract : High-performance computing is important to accelerate the numerical solutions of partial differential equations which are used for modeling high-intensity focused ultrasound and temperature. The nonlinear Westervelt equation was coupled with the bioheat equation to model temperature under ultrasound sonication. CUDA program was developed for GPU to speed up computations. An appropriate scanning pathway can help to ablate a big tumor volume uniformly within a few minutes considering that cavitation can also affect the lesion form.