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[00464] Predicting the role of poroelastic coatings for cell therapies via an asymptotic approach

• Session Time & Room : 1C (Aug.21, 13:20-15:00) @D515
• Type : Contributed Talk
• Abstract : Cell therapies are a promising alternative for treating liver disease. Encapsulation modulates the mechanical cues inflicted on a cell, which can increase engraftment at the injury site. We model an individual, hydrogel-coated stem cell translating axially along a fluid-filled channel due to a Stokes flow, obtaining semi-analytic solutions in the limit of a stiff coating. We conduct a parametric study to predict the role of coatings and discuss implications for biological cells.
• Classification : 92C37, Poroelasticity, Fluid-structure interaction, asymptotics
• Format : Talk at Waseda University
• Author(s) :
  • Simon Mark Finney (University of Oxford)
  • Sarah Louise Waters (University of Oxford)
  • Andreas Muench (University of Oxford)
  • Matthew Gregory Hennessy (University of Bristol)