[00375] Modelling Typhoid Fever Transmission: Optimal control and Cost-Effectiveness Analysis
Session Time & Room : 3C (Aug.23, 13:20-15:00) @A601
Type : Industrial Contributed Talk
Abstract : Typhoid fever has been a public health challenge globally, most especially in the developing countries where sanitation and personal hygiene are not taken serious coupled with non-availability of safe-drinking water. In this paper, a deterministic mathematical model of direct and indirect mode of transmission of Typhoid fever dynamics is formulated to investigate the influence of limited clinical efficacy of antibiotics administer to patients suffering from the disease with optimal control and cost-effectiveness analysis.
Typhoid fever has been a public health challenge globally, most especially in the developing countries where sanitation and personal hygiene are not taken serious coupled with non-availability of safe-drinking water. In this paper, a deterministic mathematical model of direct and indirect mode of transmission of Typhoid fever dynamics is formulated to investigate the influence of clinical efficacy of antibiotics administer to patients suffering from the disease. The basic reproduction number is analytically computed, and existence and local stability condition of disease-free equilibrium is investigated. Subsequently, the global sensitivity analysis of the model parameters is computed. The optimal control and cost-effectiveness analysis were also computed. Our results suggest that hygiene practice and awareness campaign, and disinfection or sterilization or bacteria decay control is the most cost-effective in eliminating the disease from the population and from preventing the susceptible individuals from contracting the bacteria disease.
