[00927] Bone marrow stem cells and exosomes control doxorubicin-induced CRCC: A mathematical model
Session Time & Room : 3E (Aug.23, 17:40-19:20) @A601
Type : Contributed Talk
Abstract : Doxorubicin (DOX), a widely used chemotherapeutic agent, can cause neurodegeneration in the brain, which leads to cancer-related cognitive changes (CRCC). In fact, CRCC is a deteriorating condition which adversely affects the day-to-day life of cancer survivors. Recent studies reported that bone marrow mesenchymal stem cells (BMSCs) and exosome may significantly affect the CRCC conditions in a combination therapy (DOX+Exosome). In this study, we investigate the interaction among intracellular signaling (NFκB-Bcl-2-BAX), DOX, exosome, and IL-6.